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It is a competitive and selectiveDPP-4 inhibitor which potentiates the action ofGLP-1 (Fig.

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These phosphorylations also aug-ment Mdm2 interaction with p300, reduce the afnity of Mdm2 for p19ARF [ 142]and inhibit Mdm2 self-ubiquitination [143] (Reviewed in [143–147]). A bulb syringe is used to clearmucous from mouth and nares. These systemshave utilized different methods of oxygenationmonitoring with pulse oximetry being the mostcommon. Intravenous PPI therapy (omeprazole 80 mg followed by infusion 8 mg/h for 72 hours).